Equipment Reference

Double Wood Supplements

Double Wood Fisetin

500mg senolytic flavonoid for monthly longevity pulses

4.4

(980 community reviews)

Double Wood Fisetin provides 500mg of fisetin per capsule — the dose used in Mayo Clinic-inspired senolytic pulse protocols. Third-party tested, excellent value for biohackers running monthly 2-day fisetin clears. Not for daily use; designed for periodic senescent cell cleanup pulses.

Used by

r/longevitySenolytic experimentersMayo Clinic protocol followers

Typical price: $20 – $28 USD / 120 capsules

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How It Works

Fisetin inhibits several pro-survival pathways in senescent cells (SCAP pathway, BCL-2 family) while sparing healthy cells. Periodic pulses reduce the burden of 'zombie cells' that secrete inflammatory cytokines accelerating tissue aging.

Senolytic Activity

Fisetin selectively induces apoptosis in senescent cells, reducing SASP inflammatory signaling.

Mayo Clinic Research

Identified as the most potent flavonoid senolytic in preclinical screens from the Kirkland lab.

Pulse Protocol

500–1000mg/day for 2 consecutive days, repeated monthly or quarterly — not daily supplementation.

What You'll Experience

Pulse Days

Days 1–2

Take 1–2 capsules (500–1000mg) with a fat-containing meal. Some report mild fatigue during the pulse.

Recovery

Days 3–7

Return to normal supplement routine. Anecdotal joint comfort and energy improvements reported by some users.

Next Cycle

Month 1–3

Repeat monthly or quarterly. Track inflammatory markers if doing bloodwork.

Benefits

Senolytic Protocol

Emerging Research

500mg per capsule matches common research-inspired pulse dosing.

Third-Party Tested

Strong Evidence

Double Wood provides COA for purity verification.

Value Pricing

Anecdotal

120 capsules supports 60+ monthly pulse cycles at 2 caps/pulse.

Risks & Considerations

Experimental Use

medium risk

Human senolytic data is preliminary. You are self-experimenting, not following proven medical guidance.

Drug Interactions

medium risk

Fisetin inhibits CYP enzymes. Caution with chemotherapy and immunosuppressants.

US Shipping Only

low risk

Double Wood primarily ships within the United States.

Community Reviews

Synthesized consensus from Reddit, forums, and expert sources.

Reddit r/longevity

Mostly Positive

Default budget fisetin pick. '500mg caps make pulsing easy — 2 days a month, done.'

·Best value fisetin on Amazon
·500mg dose matches pulse protocols
·Take with fat for absorption

View source

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Last updated: 2026-07-17 · Informational only. Not medical advice.