Topic
Supplements
Nootropics, longevity compounds, vitamins, and stacks, with evidence ratings and risk profiles.
Guides
SupplementsNAD+ & Longevity: The Complete Guide
NAD+ is one of the most critical molecules in human biology, essential for energy, DNA repair, and activating longevity pathways. Levels decline ~50% between ages 40–60. This guide explains what NAD+ does, whether supplementation works, NR vs NMN debate, and how to test your levels.
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SupplementsCreatine: The Complete Guide
Creatine monohydrate is one of the few supplements with decades of human research, not just for muscle and strength, but increasingly for brain energy, recovery, and healthy aging. This guide covers dosing, loading, what form to buy, and who actually benefits.
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SupplementsMagnesium: The Complete Guide
Up to 50% of adults may not meet optimal magnesium intake. It's involved in 300+ enzymatic reactions, sleep, muscle recovery, stress, and heart rhythm all depend on it. This guide breaks down which form to take, when, and how much.
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SupplementsBryan Johnson's Blueprint: The Complete Guide
Bryan Johnson spends ~$2M/year on his 'Don't Die' anti-aging protocol, the most measured human body in history. Blueprint includes 100+ daily supplements, precise sleep/calorie timing, plasma exchange, and relentless biomarker tracking. This guide breaks down what's evidence-based, what's experimental, and what mere mortals can actually adopt.
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SupplementsOmega-3 Fatty Acids: The Complete Guide
Omega-3 fatty acids (EPA and DHA) are essential for brain structure, cardiovascular health, and inflammation control. Most Western diets are deficient. This guide covers dosing, quality testing, the Omega-3 Index, and how to choose a fish oil.
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SupplementsVitamin D: The Complete Guide
Vitamin D is technically a hormone, involved in immunity, bone health, mood, and 200+ gene expressions. Deficiency affects ~40% of adults in temperate climates. This guide covers testing, dosing, K2 pairing, and sun vs supplement tradeoffs.
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SupplementsIntermittent Fasting: The Complete Guide
Intermittent fasting (IF) is one of the most practiced biohacks worldwide, popularized by Dave Asprey's Bulletproof approach and validated by decades of metabolic research. This guide covers 16:8 vs OMAD, ketosis timing, autophagy windows, and who should avoid fasting.
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SupplementsTestosterone Optimization: The Complete Guide
Testosterone optimization is one of the most searched biohacking topics, from natural lifestyle interventions to TRT clinics. Dave Asprey discusses hormonal health as core to vitality and longevity. This guide covers evidence-based natural optimization before pharmaceutical intervention.
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SupplementsGlutathione: The Complete Guide
Glutathione is your body's master antioxidant, present in every cell, critical for detoxification, immune function, and mitochondrial health. Dave Asprey calls it 'the most important molecule you need to stay healthy.' This guide covers why oral glutathione fails, liposomal delivery, and NAC as a precursor.
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SupplementsAshwagandha: The Complete Guide
Ashwagandha (Withania somnifera) is the most studied adaptogen in biohacking. Multiple RCTs show cortisol reduction, improved sleep, and modest strength gains. This guide compares KSM-66 and Sensoril extracts, dosing protocols, and important contraindications.
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SupplementsUrolithin A: The Complete Guide
Urolithin A is a gut microbiome metabolite that triggers mitophagy, the selective recycling of damaged mitochondria. Amazentis/Timeline's Mitopure is the first clinically validated urolithin A supplement. This guide covers the science, dosing, and who actually converts ellagic acid from food.
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SupplementsCollagen Peptides: The Complete Guide
Collagen peptides are hydrolyzed collagen protein supplements supporting skin elasticity, joint comfort, and gut lining integrity. They're also a significant dietary source of glycine. This guide covers types, dosing, evidence quality, and how collagen fits a biohacking stack.
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SupplementsL-Theanine: The Complete Guide
L-theanine is an amino acid from green tea that promotes calm alertness by increasing alpha brain waves and modulating GABA, dopamine, and serotonin. Huberman includes it in his sleep stack; others pair it with caffeine for focused productivity. This guide covers both use cases.
Read guideSupplementsVitamin K2: The Complete Guide
Vitamin K2 activates proteins that direct calcium into bones and teeth while preventing arterial calcification. It's the essential partner to vitamin D3 supplementation. This guide covers MK-4 vs MK-7 forms, dosing, and why D3 without K2 may be incomplete.
Read guideSupplementsRhodiola Rosea: The Complete Guide
Rhodiola rosea is a cold-climate adaptogen used for mental stamina, fatigue resistance, and stress buffering. Unlike sedating adaptogens, rhodiola is typically taken in the morning for calm energy. This guide covers SHR-5 and 3% rosavin extracts, dosing, and how it pairs with ashwagandha.
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SupplementsBerberine: The Complete Guide
Berberine is a plant alkaloid that activates AMPK and lowers blood glucose comparably to metformin in some trials. Biohackers use it for metabolic health, CGM optimization, and longevity signaling. This guide covers 500mg dosing, GI side effects, and CGM pairing.
Read guideSupplementsNAC (N-Acetyl Cysteine): The Complete Guide
NAC is the most bioavailable precursor to glutathione, the body's master antioxidant. Used in hospitals for acetaminophen overdose, biohackers take it for liver support, respiratory health, and oxidative stress. This guide covers 600–1200mg dosing and availability considerations.
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SupplementsCoQ10 (Ubiquinol): The Complete Guide
Coenzyme Q10 is essential for mitochondrial ATP production and is depleted by statin medications and aging. Biohackers supplement ubiquinol for energy, cardiovascular support, and exercise recovery. This guide compares forms, doses, and who benefits most.
Read guideSupplementsTongkat Ali: The Complete Guide
Tongkat ali (Eurycoma longifolia) is a Southeast Asian herb studied for raising free testosterone, reducing cortisol, and improving libido in men with low-normal T. This guide covers LJ100 and Physta extracts, 200–400mg dosing, and blood test monitoring.
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SupplementsZinc: The Complete Supplement Guide
Zinc is an essential trace mineral involved in 300+ enzymatic reactions, immune function, testosterone production, wound healing, and sleep regulation. Mild deficiency is common in athletes, vegetarians, and those with high sweat losses. This guide covers forms, dosing, copper balance, and who actually needs to supplement.
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SupplementsProbiotics: Strains, Evidence, and What Actually Works
The probiotic market is a $60B mess of underdosed, poorly studied products. But specific strains with clinical trial data can meaningfully support gut health, immune function, and even mood. This guide cuts through marketing to cover evidence-backed strains, dosing in CFUs, spore vs conventional probiotics, and when testing beats guessing.
Read guideSupplementsSpermidine: Autophagy, Longevity, and Food Sources
Spermidine is a naturally occurring polyamine found in wheat germ, aged cheese, and mushrooms. It activates autophagy, the cellular cleanup process linked to longevity. Human epidemiological data shows higher dietary spermidine intake correlates with reduced cardiovascular and cancer mortality. This guide covers food sources, supplemental dosing, and how it fits into a longevity stack.
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SupplementsShilajit: Fulvic Acid, Minerals, and the Evidence
Shilajit is a tar-like resin from Himalayan rock, used in Ayurvedic medicine for centuries. Modern interest centers on fulvic acid content, mineral delivery, testosterone support, and mitochondrial function. The evidence is thin but intriguing. The bigger concern: heavy metal contamination in low-quality products. This guide covers what shilajit actually is, what research exists, dosing, and how to source clean resin.
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SupplementsAG1 & Greens Powders: Worth It or Overpriced?
AG1 (Athletic Greens) is the most marketed greens powder in biohacking — 75 ingredients in one scoop. Tim Ferriss and Huberman popularized it as nutritional insurance. This guide breaks down what's actually in greens powders, whether the $80/month price is justified, and how AG1 compares to DIY stacks and whole food.
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SupplementsFisetin & Senolytics: Clearing Zombie Cells
Senolytics are compounds that selectively kill senescent ('zombie') cells — damaged cells that stop dividing but refuse to die, secreting inflammatory signals that accelerate aging. Fisetin, a flavonoid found in strawberries, showed the strongest senolytic activity in Mayo Clinic screens. Human data is early but the biohacking community treats fisetin pulses as a tier-2 longevity intervention.
Read guideReferenced Equipment
Equipment from our guides, with specs and trusted purchase links.
ChromaDex / Tru Niagen
Tru Niagen (NR)
NAD+ precursor for cellular energy and longevity
AG1 / Athletic Greens
AG1 (Athletic Greens)
The daily greens supplement every biohacker debates
Thorne
Thorne Creatine Monohydrate
Creapure-certified creatine for muscle and brain performance
Thorne
Thorne Magnesium Bisglycinate
Highly absorbable glycinate for sleep, recovery, and stress
Bulletproof
Bulletproof Brain Octane Oil
Pure C8 MCT oil, the ketone fuel behind Bulletproof Coffee
Four Sigmatic
Four Sigmatic Lion's Mane Elixir
Mushroom nootropic coffee, the beginner's smart drug
Nordic Naturals
Nordic Naturals Ultimate Omega
IFOS-certified fish oil, the gold standard for EPA+DHA
Timeline Nutrition
Timeline Mitopure
Clinically validated urolithin A for mitochondrial health and muscle endurance
Kion
Kion Ashwagandha (KSM-66)
Full-spectrum root extract for cortisol reduction and stress resilience
Vital Proteins
Vital Proteins Collagen Peptides
Grass-fed bovine collagen for skin, joints, and morning coffee rituals
Double Wood Supplements
Double Wood L-Theanine
200mg capsules for Huberman sleep stack and caffeine pairing
Thorne
Thorne Vitamin D/K2 Liquid
Combined D3 + K2 drops for calcium routing and bone health
Thorne
Thorne Berberine-500
500mg berberine HCl for glucose control and AMPK activation
Thorne
Thorne NAC
500mg N-acetyl cysteine for glutathione support and liver health
Life Extension
Life Extension Super Ubiquinol CoQ10
100mg Kaneka ubiquinol with shilajit for mitochondrial energy
Double Wood Supplements
Double Wood Tongkat Ali
400mg Eurycoma longifolia extract for free testosterone support
LMNT
LMNT Electrolytes
Sugar-free sodium-potassium-magnesium for fasting, keto, and training
Thorne
Thorne Zinc Picolinate
Highly absorbable zinc for immune support and mineral repletion
Seed
Seed DS-01 Daily Synbiotic
24-strain probiotic + prebiotic with published clinical data
Double Wood Supplements
Double Wood Fisetin
500mg senolytic flavonoid for monthly longevity pulses
Life Extension
Life Extension Low-Dose Methylene Blue
Pharmaceutical-grade 50mg capsules for micro-dose nootropic protocols